Pinpointe allows you to send campaigns using different send-from / reply-to addresses for different campaigns. You are not limited to using a single send-from and reply-to address.  When you set up a user, a contact list, and when you are sending out an email, you are given the opportunity to set any name and email address that you wish for the contacts to receive mail from. 

Pinpointe will then send the email out with the From and Reply-To headers set to your preference.

Each user can set up their own details and even change them for individual sends.